WORKSHOP DAY - TUESDAY 1ST DECEMBER 2020

IO PKPD-Bootcamp

Workshop Leader

Hitesh Mistry
Clinical Pharmacometrics, Biostatistics, Data Science Senior Research Fellow
University of Manchester

Using Software to Tackle the In Vivo Reproducibility Crisis & Address the 3R

Workshop Leader

Chris Armstrong
CEO
Overwatch Research

Looking at the Big Picture in Preclinical Translation

Workshop Leader

Andrew Pierce
Vice President - Translational Biology
Crescendo
Biologics

Workshop A

IO PKPD-Bootcamp

9:30 am-11:30 am

Preclinical PK/PD analysis is increasingly being included in regulatory submissions. In this workshop we will focus on PK/PD principles for both small and large molecule IO candidates that can assist in the selection/optimisation of doses/dose regimens, including prediction of human efficacious doses. The workshop will provide examples of how PK/PD principles can assist in partially explaining why many candidates don’t behave the same way in the clinic as in preclinical models.

Hitesh Mistry Uni o Man

 

Workshop Leader

Hitesh Mistry
Clinical Pharmacometrics, Biostatistics, Data Science Senior Research Fellow
University of Manchester

Workshop B

Using Software to Tackle the In Vivo Reproducibility Crisis & Address the 3R

12.00pm - 3.00pm

In this workshop we will discuss:

  • The impact of irreproducibility in pre-clinical in vivo research
  • How irreproducibility can directly impact our ability to adhere to the three Rs
  • The importance of user-focused design when implementing a solution aimed at improving reproducibility
  • How Overwatch in vivo study management software can improve reproducibility in your organization via the implementation of modern technologies. This will include hands-on experience

 

Chris Armstrong Overwatch

Workshop Leader

Chris Armstrong
CEO
Overwatch Research

Workshop C

Looking at the Big Picture in Preclinical Translation

3:50 pm-5:30 pm

  • Gain clarity and understanding on useful and realistic end points to translate your immune-oncology therapy into the clinic; what are regulators and internal/external stakeholders looking for?
  • Guide your preclinical strategy to accelerate the success of your therapeutic pipeline and de-risk clinical trials.
  • How to harmonize preclinical studies with the translational science of early clinical development
Andrew Pierce Crescendo

Workshop Leader

Andrew Pierce
Vice President - Translational Biology
Crescendo
Biologics