Development of NK Humanized Mice Models for the In Vivo Evaluation of NK Cells Engagers and/or Immune-Modulators Targeting NK Cells

Time: 8:40 am
day: Day One


  • Development of robust in vivo models that allow the engraftment and maintenance of fully functional human NK cells
  • Evaluation of several strains of immunodeficient transgenic mice for human cytokines (IL-15)
  • Determination of optimal parameters of NK engraftment
  •  In vivo efficacy pilot studies in these NK humanized mice models using an anti-CD20 Ab