Joshua Breunig

Joshua Breunig

Company: Cedars-Sinai Medical Center & UCLA

Job title: Associate Professor, Director, Brain Program

Seminars:

Deciphering Distinct Tumour Life Histories In Vivo with Somatic Transgenic Evolving Barcodes & Single-Cell Sequencing 11:40 am

How can genetic barcodes deconvolute the patterns of progression of different tumour types? Detection of Clonal sweeps versus other patterns of evolution Could this have the capacity to inform clinical standard-of-care or predict clinical success Discussion of future applications of the method Lessons learnt from technical challenges (germ line recombination, low barcode recovery issues, and…Read more

day: Day Two

Fireside Chat: Food for Thought: What Are the Implications Of Model Characteristics? 10:00 am

Inflamaging: Potential Implications of Gender And Age Of Models Compared To Disease How are people modelling the age/sex disparities of disease modalities? The affect of immunological age on the immune response and thereby gaining an understanding of altered disease progression. Why are age and sex underrepresented in the research/not empirically represented? Sharing best practices of…Read more

day: Day Two

Roundtable discussion: Exploring Regulatory Guidelines & Best Practices for Model Developers 8:30 am

Exploring the current regulatory guidelines in incorporating regulatory body guidelines into models Understanding how this applies in the context of genetic medicines Sharing best practices of patient input at different stages of development Which alternative model is likely to be the next approved regulatory method? What techniques are regulators considering accepting (other than animal models)…Read more

day: Day Two

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