Employing Preclinical Findings from Advanced Tumour Models to Ensure the Successful Translation of Small Molecule Therapies to the Clinic
- Spotlighting lessons learned taking a small molecule from discovery to the clinic and the types of models that were used
- Nurturing relationships with CROs and academic groups to leverage cancer-associated fibroblast (CAF) models and orthotopic models for preclinical studies
- Identifying biomarkers that can predict response to Wnt, aiding in patient stratification and the design of clinical trials