Harnessing Genetically Engineered Mouse Models (GEMMs) to Decode Cancer Pathogenesis & Resistance
- Spotlighting techniques to add controlled mutations to replicate the sporadic and progressive nature of B-cell lymphomas, from early transformation to full-blown malignancy
- Utilising complex GEMMs to investigate mechanisms of treatment failure and resistance, enabling deeper insights into therapeutic vulnerabilities and relapse dynamics
- Developing models that capture pre-malignant and early malignant states to study immune cell development, tumour initiation, and the potential for early intervention strategies