Optimising Spheroid Co-Cultures & PDX models to Empower the Translation of FAP-Enabled pre|CISION®-Peptide Drug Conjugates
- Highlighting the background of fibroblast activation protein (FAP)-enabled pre|CISION®-peptide drug conjugates (PDCs) and the rationale for model selection
- Sharing best practices for developing co-cultures of tumour cells and human primary FAP+ fibroblasts to assess bystander activity of PDCs in physiologically relevant systems
- Characterising PDCs using CDX, PDX models, and spheroid co-cultures to better understand their mechanism of action