Uncovering the Translational Relevance of Humanised Mouse Models for the Development of Off-the-Shelf T Cell Engagers
- Exploring the development and application of fully humanised in vivo systems to replicate human immune responses and tumour biology, enabling robust evaluation of immunotherapies
- Demonstrating how this humanised model yielded clinically relevant data in diseases such as lymphoma and myeloma, with a focus on T cell engagers and co-stimulatory pathways
- Discussing how these models complement advanced in vitro systems and support decision-making across the drug development pipeline, from early efficacy to translational validation