Dinis Calado
Senior Group Leader The Francis Crick Institute
Dinis Calado, PhD, is a leading immunologist whose research explores lymphocyte development, hematopoietic malignancies, and tumour-host interactions. His work focuses on the molecular mechanisms driving lymphoproliferative diseases, with a particular interest in the role of microRNAs in lymphocyte physiology and lymphomagenesis. Through his research, Dinis contributes to advancing our understanding of immune system regulation and its implications for cancer biology and therapy.
Seminars
Wednesday 3rd December 2025
Harnessing Genetically Engineered Mouse Models (GEMMs) to Decode Cancer Pathogenesis & Resistance
11:00 am
- Spotlighting techniques to add controlled mutations to replicate the sporadic and progressive nature of B-cell lymphomas, from early transformation to full-blown malignancy
- Utilising complex GEMMs to investigate mechanisms of treatment failure and resistance, enabling deeper insights into therapeutic vulnerabilities and relapse dynamics
- Developing models that capture pre-malignant and early malignant states to study immune cell development, tumour initiation, and the potential for early intervention strategies
