Peter Ashcroft
Principal Scicentist II Novartis AG
Peter Ashcroft, PhD, is a Modeling & Simulation scientist at Novartis Biomedical Research. His expertise is the development and application of translational PK/PD and QSP models, spanning cancer evolution, hematology kinetics, antibiotic resistance emergence, infectious disease dynamics, and drug development for multiple therapeutic modalities across disease areas. Peter completed his undergraduate and graduate studies at The University of Manchester, UK and received his PhD in Theoretical Physics in 2015. He continued as a postdoc at ETH Zürich, Switzerland, before joining the Modeling & Simulation group at Novartis Biomedical Research.
Seminars
Thursday 4th December 2025
Combining Mathematical Models & Preclinical Models for the Translational Development of CAR-T Cell Therapies
2:00 pm
- Informing the clinical starting dose for novel CAR-T cells by benchmarking against clinically-utilized CAR-T products in mouse models
- Optimizing the translational approach for the allometric scaling of CAR-T cellular kinetics between mouse models and patients
- •Uncovering the translational relevance and predictability of different preclinical mouse models through a mathematical modeling approach for CAR-T cells
