Combining Mathematical Models & Preclinical Models for the Translational Development of CAR-T Cell Therapies
- Informing the clinical starting dose for novel CAR-T cells by benchmarking against clinically-utilized CAR-T products in mouse models
- Optimizing the translational approach for the allometric scaling of CAR-T cellular kinetics between mouse models and patients
- •Uncovering the translational relevance and predictability of different preclinical mouse models through a mathematical modeling approach for CAR-T cells